Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene
نویسندگان
چکیده
منابع مشابه
Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.
The switching of ADP-ribosylation factors from the inactive form to the active form is catalyzed by ARF-GEF (ADP ribosylation factor--guanine nucleotide exchange protein) proteins containing a Sec7 domain. The murine Arfgef2 gene encoding the BIG2 protein belongs to the class of high molecular mass (>100 kDa) ARF-GEF proteins. BIG2 is believed to be associated with the trans-Golgi network and t...
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ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2010
ISSN: 0214-6282
DOI: 10.1387/ijdb.092959pg